The ability of autologous nerve segments interposed between allografts, to increase
the total nerve-gap distance, was studied. Sciatic nerve allografts were carried out
in a rat model. A 15-mm nerve gap was repaired with a 25-mm nerve graft (interposed
group: allo-auto-allograft; control group: allo-allo-allograft). Cyclosporin was given
for 12 weeks. Nerve regeneration was evaluated using the weight of the anterior tibial
muscle and histologic, morphometric and immunohistochemical analyses at 12, 13, 14,
15, 16, 20, and 24 weeks. Nerve regeneration in the interposed group was statistically
significantly better than that in the control group. The authors concluded that a
nerve allograft with interposed autograft may enhance nerve regeneration in this model,
because of the migration of host-derived Schwann cells into the graft from not only
the proximal and distal host nerve stumps, but also the interposed autograft.
KEYWORDS
Peripheral nerve allograft - nerve regeneration - interposed nerve graft - immunohistochemistry
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Naoki SugitaM.D.
Department of Orthopaedic Surgery, JR Hiroshima General Hospital
3-1-36, Futabanosato, Higashi-ku
Hiroshima 732-0057, Japan
